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外2020 (IF 5.437)刘汉军-TMS言语
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The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com Cerebral Cortex, 2020;00: 1–13 doi: 10.1093/cercor/bhaa054 Original Article O R I G I N A L A RT I C L E Top–Down Inhibitory Mechanisms Underlying Auditory–Motor Integration for Voice Control: Evidence by TMS Dongxu Liu1, Guangyan Dai1, Churong Liu2, Zhiqiang Guo3, Zhiqin Xu1, Jeffery A. Jones4, Peng Liu1 and Hanjun Liu1,5 1Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China, 2Rehabilitation Training Center, Guangzhou 999 Brain Hospital, Guangzhou 510510, China, 3Department of Computer Science and Technology, Zhuhai College of Jilin University, Zhuhai 519041, China, 4Psychology Department and Laurier Centre for Cognitive Neuroscience, Wilfrid Laurier University, Waterloo, Ontario, Canada and 5Guangdong Provincial Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China Address correspondence to Hanjun Liu, PhD, Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China. Email: lhanjun@mail.sysu.edu.cn Dongxu Liu and Guangyan Dai have contributed equally to this work Abstract The dorsolateral prefrontal cortex (DLPFC) has been implicated in auditory–motor integration for accurate control of vocal production, but its precise role in this feedback-based process remains largely unknown. To this end, the present event-related potential study applied a transcranial magnetic stimulation (TMS) protocol, continuous theta-burst stimulation (c-TBS), to disrupt cortical activity in the left DLPFC as young adults vocalized vowel sounds while hearing their voice unexpectedly shifted upwards in pitch. The results showed that, as compared to the sham condition, c-TBS over left DLPFC led to significantly larger vocal compensations for pitch perturbations that were accompanied by significantly smaller cortical P2 responses. Source localization analyses revealed that this brain activity pattern was the result of reduced activation in the left superior frontal gyrus and right inferior parietal lobule (supramarginal gyrus). These findings demonstrate c-TBS-induced modulatory effects of DLPFC on the neurobehavioral processing of vocal pitch regulation, suggesting that disrupting prefrontal function may impair top–down inhibitory control mechanisms that prevent speech production from being excessively influenced by auditory feedback, resulting in enhanced vocal compensations for feedback perturbations. This is the first study that provides direct evidence for a causal role of the left DLPFC in auditory feedback control of vocal production. Key words: auditory feedback, continuous theta-burst stimulation, dorsolateral prefrontal cortex, speech motor control, transcranial magnetic stimulation Downloaded from https://academic.oup.com/cercor/advance-article-abstract/doi/10.1093/cercor/bhaa054/5799020 by South China Agricultural University user on 09 March 2020

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