设为首页收藏本站
CopyRight 2012-2014 DS文库版权所有
外2018 (IF 2.173 Neuroscience Letters)低频rTMS刺激双侧DLPFC对广泛性焦虑的疗效Xianju Zhou
(0 次评价)111 人阅读0 次下载
Contents lists available at ScienceDirect Neuroscience Letters journal homepage: www.elsevier.com/locate/neulet Research article The effect of bilateral low-frequency rTMS over dorsolateral prefrontal cortex on serum brain-derived neurotropic factor and serotonin in patients with generalized anxiety disorder Rulan Lu1, Chengliang Zhang1, Yanyan Liu, Linxiao Wang, Xia Chen, Xianju Zhou Laboratory of Neurological Disease, Department of Neurology, Changzhou No. 2 People’s Hospital, The Affiliated Hospital of Nanjing Medical Univeristy, Changzhou, Jiangsu, 213003, China A R T I C L E I N F O Keywords: Generalized anxiety disorder Repetitive transcranial magnetic stimulation Brain-derived neurotropic factor Serotonin A B S T R A C T To investigate the effect of bilateral low-frequency repetitive transcranial magnetic stimulation (rTMS) over dorsolateral prefrontal cortex on serum brain-derived neurotropic factor (BDNF) and serotonin (5-HT) in pa- tients with generalized anxiety disorders (GAD). As compared with before treatment, the HARS score in patients markedly decreased after treatment, and the levels of serum BDNF and 5-HT were significantly higher. Pearson correlation analysis revealed that the increase in the level of serum 5-HT was positively associated with the increase of the level of serum BDNF, and the change of anxiety score was negatively associated with the change of the level of serum BDNF and 5-HT. The results suggested that alleviation of GAD by bilateral low-frequency rTMS may be involved in the increase of the level of BDNF and the release of 5-HT in the brain. 1. Introduction Generalized anxiety disorder (GAD) is one of common anxiety dis- orders characterized by pathological anxious worrying [1–3]. GAD patients undergo difficulties in emotion intensity, expression and modulation [4]. In the clinical practice, pharmacotherapy and cogni- tive–behavioral therapy effectively ameliorate anxious symptoms [5,6]. Recently, repetitive transcranial magnetic stimulation (rTMS), as a non- invasive neuro-stimulation technique, has also shown a success in al- leviating anxiety [7,8]. rTMS alters electrical activity of brain regions by a magnetic coil through the skull [9]. Generally speaking, low-fre- quency rTMS decreases brain excitability, whereas high-frequency rTMS increases brain excitability [10]. In the past, although there is evidence that high-frequency rTMS effectively alleviates anxiety [11], investigators often applied low frequency rTMS over right dorsolateral prefrontal cortex (DLPFC) to treat anxiety disorders [2,12]. In- dependent of stimulation frequency, the therapeutic effect of rTMS may also be attributed to its specific magnetic effect. Previous fMRI studies indicated that the bilateral frontal lobes in the anxiety patients showed abnormal high signal [13]. Thus we speculated that bilateral low-fre- quency rTMS over DLPFC would lead to an extensive reduction in brain excitability. In this study, we tried to observe the effects of bilateral low-frequency rTMS over DLPFC for the treatment of GAD. Although rTMS treatment is effective for GAD patients, the potential neurobiological mechanisms are still unclear. Yulug et al showed that rTMS may exert a significant neuroprotective effect by reducing oxi- dative injury and stressful responses, enhancing the level of brain de- rived neurotrophic factor expression(BDNF) in the brain [14].There is evidence that anxiety disorders were associated with the expression of BDNF [15]. For instance, acute stress reduced the expression of BDNF mRNA in the hippocampus [16].Moreover, decreased serum BDNF le- vels were found in patients in a status of stress or depression [17]. It is known that a decrease in the levels of 5-HT is associated with anxiety [18]. One of the most identified functions of 5-HT in the adult brain is its regulation of mood, such as depression and anxiety [19,20]. Most importantly, administration of selective 5-HT reuptake inhibitors (SSRIs) is widely used to treat depression and anxiety by increasing 5- HT concentration in the synaptic cleft [21]. Accumulating evidence suggests that BDNF improves the development and function of ser- otonergic neurons [22]. Conversely, BDNF expression and signaling is under the regulation of 5-HT [16]. Therefore, there is interaction of BDNF and 5-HT which plays a role in mood disorders. In this study, we wanted to know the effects of bilateral LF rTMS over DLPFC on serum BDNF and 5-HT concentrations indirectly reflecting the corresponding change in the brain, and further analyzed their correlations. https://doi.org/10.1016/j.neulet.2018.07.008 Received 30 November 2017; Received in revised form 22 June 2018; Accepted 5 July 2018 Corresponding auhtor. 1 These authors contributed equally to thiswork. E-mail address: xianju_zhou@yahoo.com (X. Zhou). Neuroscience Letters 684 (2018) 67–71 Available online 06 July 2018 0304-3940/ 2018 Elsevier B.V. All rights reserved. T

打分:

0 星

用户评论:

zj242970502
于 2020-04-04 上传
分享的是美德,收获的是知识! 加入分享吧 立即注册

  鄂ICP备18026110  鄂公网安备 42018502002448号脑文库

1513904263 400-800-8888

Powered by Discuz! X3.2 © 2001-2013 Comsenz Inc.

返回顶部