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外2015 (IF 2.806)rTMS改善PSTD大鼠的焦虑行为和损伤的感觉门控Hua-ning Wang,Qingrong Tan YRD CCY-I
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RESEARCH ARTICLE Repetitive Transcranial Magnetic Stimulation Ameliorates Anxiety-Like Behavior and Impaired Sensorimotor Gating in a Rat Model of Post-Traumatic Stress Disorder Hua-ning Wang1, Yuan-han Bai1, Yun-chun Chen1, Rui-guo Zhang1, Huai-hai Wang1, Ya- hong Zhang1, Jing-li Gan2, Zheng-wu Peng1*, Qing-rong Tan1* 1 Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China, 2 Department of Psychiatry, 91 Hospital of P. L. A., Jiaozuo, 454150, China These authors contributed equally to this work. * pengzhengwu1446@163.com (Z-WP); tanqingr@fmmu.edu.cn (Q-RT) Abstract Background Repetitive transcranial magnetic stimulation (rTMS) has been employed for decades as a non-pharmacologic treatment for post-traumatic stress disorder (PTSD). Although a link has been suggested between PTSD and impaired sensorimotor gating (SG), studies as- sessing the effects of rTMS against PTSD or PTSD with impaired SG are scarce. Aim To assess the benefit of rTMS in a rat model of PTSD. Methods Using a modified single prolonged stress (SPS&S) rat model of PTSD, behavioral parame- ters were acquired using open field test (OFT), elevated plus maze test (EPMT), and pre- pulse inhibition trial (PPI), with or without 7 days of high frequency (10Hz) rTMS treatment of SPS&S rats. Results Anxiety-like behavior, impaired SG and increased plasma level of cortisol were observed in SPS&S animals after stress for a prolonged time. Interestingly, rTMS administered immedi- ately after stress prevented those impairment. Conclusion Stress-induced anxiety-like behavior, increased plasma level of cortisol and impaired PPI occur after stress and high-frequency rTMS has the potential to ameliorate this behavior, PLOS ONE | DOI:10.1371/journal.pone.0117189 February 6, 2015 1 / 15 OPEN ACCESS Citation: Wang H-n, Bai Y-h, Chen Y-c, Zhang R-g, Wang H-h, Zhang Y-h, et al. (2015) Repetitive Transcranial Magnetic Stimulation Ameliorates Anxiety-Like Behavior and Impaired Sensorimotor Gating in a Rat Model of Post-Traumatic Stress Disorder. PLoS ONE 10(2): e0117189. doi:10.1371/ journal.pone.0117189 Academic Editor: Gabriel Alejandro de Erausquin, University of South Florida, UNITED STATES Received: September 26, 2012 Accepted: December 21, 2014 Published: February 6, 2015 Copyright: 2015 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: This work was supported by grants from the National Key Technology R & D Program of China (No.2009BA177B09) and the Natural Science Foundation of China (No. 81201041, 81371478 and 81401109). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: The authors have declared that no competing interests exist.

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